Have you seen Garfield Minus Garfield? The book has been out since October 2008, collected from the comics posted on Dan Walsh’s website. The gist is to remove the cat from the strip and discover a remarkably funny, albeit dark and usually depressing, comic strip.
Publishers Weekly says, “If Samuel Beckett had been a strip cartoonist, he might’ve produced something like this.” Here are a couple.
For a slightly different angle on this joke: